Grey's Anatomy is an American medical drama television series focusing on the personal and professional lives of surgical interns, residents, and attendings at the fictional Seattle Grace Hospital, later named the Grey Sloan Memorial Hospital. The series premiered on March 27, 2005, on ABC as a mid-season replacement. The show's title is a reference to Gray's Anatomy, a classic human anatomy textbook. Writer Shonda Rhimes developed the pilot and served as showrunner, head writer, and executive producer until stepping down in 2015. Set in Seattle, Washington, the series is filmed primarily in Los Angeles, California, and Vancouver, British Columbia.